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We treated 22 patients with subacute sclerosing panencephalitis(SSPE)with intraventricular a-interferon(a-IFN)and oral inosiplex between 1986 and 1991.The follow-up for 56 to 108 months demonstrates a higher survival rate in these patients compared with those who did not receive a-IFN. However,eight of 11 patients whose condition improved after a-IFN treatment and five of five patients whose condition improved after a-IFN experienced neurologic deterioration 6 to 90 months after treatment;three of 11 and four of five died.The use of inosiplex did not influence the prognosis.Re-administration of the same regimen was not effective in one patient.Treatment-induced remissions in SSPE can be temporary,analogous to spontaneous remissions.Longer treatment with higher doses,or combinations of drugs,may be required. |
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